Is Panadol a painkiller – How Pain killers work on the body – Truth about Painkillers !! We need painkillers more than often we can imagine their role in our lives. It’s used in case of Post-surgical pain management, Diseases involving Excruciating pain, Fever, Or any anomaly regarding pain management For these, doctors prescribe various pain killers for the management of acute to moderate to severe pain depending upon a particular patient,
There are three main types of painkillers:
non-steroidal anti-inflammatory drugs, paracetamol, and opioids. Each works in a different way. Most people only need to take painkillers for a few days or weeks at most, but some people need to take them for a long time. They can be taken in a variety of forms such as,
By mouth as liquids, tablets, or capsules.
or into the rectum as suppositories.
Mechanisms of Action
Once ingested, they act on the body through various types of mechanisms. The human brain receives signals of pain from different parts of the body and processes them in the pain centers of the brain. These painkillers act to block pain signals to reach the brain and hence pain is not felt by the brain. The Cyclooxygenase enzyme is responsible for the production of chemicals that mediate pain. So when this enzyme is blocked by these drugs, the patient feels relieved of pain The Non-steroidal anti-inflammatory drugs. Examples include ibuprofen, Diclofenac and naproxen, and aspirin. However, it is mainly prescribed in low doses to help to keep the blood from clotting, for people who have had a heart attack in the past to prevent the likelihood of another such event so that your heart keeps pumping normally.
These work by blocking cyclooxygenase. They reduce pain and inflammation so these drugs are usually prescribed for inflammatory diseases such as arthritis, gout, and systemic lupus erythematosus. Paracetamol is thought to work by blocking cycloxygenase enzymes in the brain and spinal cord. Paracetamol is used to treat pain and lower a high temperature. Paracetamol is normally prescribed if your pain is not too serious and you do not have inflammation. Opioids work by binding to certain receptors, the opioid receptors in your central nervous system, your gut, and other parts of your body. This leads to a decrease in the way you feel pain and your reaction to pain and it increases your tolerance for pain. Opioids are usually prescribed for more severe pain or if you have tried other drugs and they have not worked.
There are some differences among various painkiller as aspirin can irritate the stomach and delays blood clotting and it is anti-inflammatory as well in comparison to acetaminophen. However, pain management is the key ingredient in these drugs. Each drug is suitable for a specific person and must be consulted with a doctor.
Side effects of painkiller
Side effects include nausea, internal bleeding, vomiting, liver damage, constipation, breathing difficulty, dry mouth, hypersensitivity, headache, electrolyte imbalance, dizziness, and Reyes’ syndrome. These are over-the-counter drugs easily available and it can lead to scenarios of overconsumption leading to toxicity and death. In case of toxicity are there any antidotes available? To answer this question there is an antidote available called NAC but time is of the essence. If the antidote is given in the first few hours of overdosage, it leads to full recovery and the patient does not fall ill. But if unforeseen circumstances occur and an antidote is not given in due time, it leads to liver toxicity and can lead to death as a result of liver failure.